Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

Peter J. Whitehouse, Donald L. Price, Arthur W. Clark, Joseph T. Coyle, Mahlon R. DeLong

1981Published

1.5KCitations

0References

journal articleType

Abstract

AbstractThe nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.

Journal: Annals of Neurology

Publisher: Wiley

View on DOI

Citations are the number of DOI-registered works in Crossref that cite this paper; references are how many works it cites. Full text is on the publisher site via the DOI link.