Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

John G Doench, Ella Hartenian, Daniel B Graham, Zuzana Tothova, Mudra Hegde, Ian Smith, Meagan Sullender, Benjamin L Ebert, Ramnik J Xavier, David E Root

Journal: Nature Biotechnology

Publisher: Springer Science and Business Media LLC

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