Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Nuno R. Faria, Thomas A. Mellan, Charles Whittaker, Ingra M. Claro, Darlan da S. Candido, Swapnil Mishra, Myuki A. E. Crispim, Flavia C. S. Sales, Iwona Hawryluk, John T. McCrone, Ruben J. G. Hulswit, Lucas A. M. Franco, Mariana S. Ramundo, Jaqueline G. de Jesus, Pamela S. Andrade, Thais M. Coletti, Giulia M. Ferreira, Camila A. M. Silva, Erika R. Manuli, Rafael H. M. Pereira, Pedro S. Peixoto, Moritz U. G. Kraemer, Nelson Gaburo, Cecilia da C. Camilo, Henrique Hoeltgebaum, William M. Souza, Esmenia C. Rocha, Leandro M. de Souza, Mariana C. de Pinho, Leonardo J. T. Araujo, Frederico S. V. Malta, Aline B. de Lima, Joice do P. Silva, Danielle A. G. Zauli, Alessandro C. de S. Ferreira, Ricardo P. Schnekenberg, Daniel J. Laydon, Patrick G. T. Walker, Hannah M. Schlüter, Ana L. P. dos Santos, Maria S. Vidal, Valentina S. Del Caro, Rosinaldo M. F. Filho, Helem M. dos Santos, Renato S. Aguiar, José L. Proença-Modena, Bruce Nelson, James A. Hay, Mélodie Monod, Xenia Miscouridou, Helen Coupland, Raphael Sonabend, Michaela Vollmer, Axel Gandy, Carlos A. Prete, Vitor H. Nascimento, Marc A. Suchard, Thomas A. Bowden, Sergei L. K. Pond, Chieh-Hsi Wu, Oliver Ratmann, Neil M. Ferguson, Christopher Dye, Nick J. Loman, Philippe Lemey, Andrew Rambaut, Nelson A. Fraiji, Maria do P. S. S. Carvalho, Oliver G. Pybus, Seth Flaxman, Samir Bhatt, Ester C. Sabino

2021Published

1.2KCitations

0References

journal articleType

Abstract

Unmitigated spread in Brazil Despite an extensive network of primary care availability, Brazil has suffered profoundly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Using daily data from state health offices, Castro et al. analyzed the pattern of spread of COVID-19 cases and deaths in the country from February to October 2020. Clusters of deaths before cases became apparent indicated unmitigated spread. SARS-CoV-2 circulated undetected in Brazil for more than a month as it spread north from Sã o Paulo. In Manaus, transmission reached unprecedented levels after a momentary respite in mid-2020. Faria et al. tracked the evolution of a new, more aggressive lineage called P.1, which has 17 mutations, including three (K417T, E484K, and N501Y) in the spike protein. After a period of accelerated evolution, this variant emerged in Brazil during November 2020. Coupled with the emergence of P.1, disease spread was accelerated by stark local inequalities and political upheaval, which compromised a prompt federal response. Science , abh1558 and abh2644, this issue p. 821 and p. 815

Journal: Science

Publisher: American Association for the Advancement of Science (AAAS)

View on DOI

Citations are the number of DOI-registered works in Crossref that cite this paper; references are how many works it cites. Full text is on the publisher site via the DOI link.